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Product Development Of Many Different Formulations
Creams
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Creams are semi-solid preparations in which active ingredients are dissolved or dispersed in an emulsion base. They have a uniform and fine texture, good stability, and are suitable for patients with eczema or dermatitis who need relief from dryness and sustained drug delivery. Creams can act directly on the target skin area, reduce systemic exposure, and allow gradual penetration into the skin.
Ointments
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Ointments are semi-solid topical preparations made by mixing active ingredients with suitable bases. They are uniform, smooth, and generally non-irritating to the skin. Ointments can protect wounds, lubricate the skin, and provide local therapeutic effects with rapid onset.
Gels
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Gels are thick liquid or semi-solid preparations made with excipients that form a gel structure. They may be solution, suspension, or emulsion-based. Gels are light, refreshing, non-greasy, and provide a cooling sensation. They allow slow and sustained drug release and are suitable for scenarios requiring a light skin feel and long-lasting delivery.
Solutions
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Solutions are clear liquid preparations formed by dissolving active ingredients in a solvent. They offer good penetration and are suitable for rapid onset or targeted application. When used with a spray head, they can act directly on the skin surface, support rapid antimicrobial action, help reduce environmental fungi, and provide convenient and hygienic use.
Sprays
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Sprays are preparations delivered as fine droplets through a pump system. The drug can reach the target area directly, providing high local concentration and rapid onset. Sprays offer accurate dosing, convenience, and hygiene, and are suitable for areas that are difficult to apply by hand or require precise administration.
Liniments
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Liniments are liquid preparations used by rubbing onto intact skin. They may be applied directly or placed on dressings for local use. Liniments can provide analgesic, protective, and counter-irritant effects. They are light, easy to absorb, non-greasy, and support targeted and comfortable application.
Film-Forming Topical Preparations
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Film-forming topical preparations are external preparations made by dissolving film-forming materials and active ingredients in organic solvents. After application, the solvent evaporates and forms a thin film on the affected area. This film helps protect the skin surface while allowing gradual drug release, making it suitable for scenarios requiring both protection and long-lasting delivery.
Lotions
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Lotions are external liquid preparations used for application, wet dressing, or rinsing of the skin. They may provide cleansing, disinfection, anti-inflammatory, antipruritic, cooling, and astringent effects, and are suitable for skin rinsing, sitz baths, or topical treatment.
Topical medicine products are very complex. Their development faces multiple challenges, including complex structures, complex compositions, and specific delivery requirements.
Active ingredients must penetrate the stratum corneum and reach target tissues while minimizing irritation. Products must also maintain good stability and a pleasant user experience to support patient adherence.
From small-scale research to commercial production, topical formulations also face scale-up challenges. Multiphase systems are highly sensitive to process parameters such as shear force and temperature control, making large-scale manufacturing technically demanding.
Compound antioxidant technology
Poly-emulsification technology
Packaging system research technology
Microstructure research technology
Mass spectrometry imaging, MSI, and high-sensitivity LC-MS/MS technology
Fully automated transdermal diffusion system
Tape stripping technology
Process scale-up parameter optimization based on data accumulation
Real-time online monitoring of key process indicators
Embedded GMP-compliant scale-up management throughout the full process
Appearance and texture characterization,
Emulsion type characterization,pH value,
Phase characterization,Particle size,
Oil phase characterization,Crystal form,
Rheological properties,Crystal habit,
Oil phase characterization,Crystal form,
Specific gravity,Droplet size,Drying rate,
Moisture content,Water activity,
Deformation-related properties
......
ZIYOND has built a comprehensive treatment layout in China’s dermatology market, covering skin health needs from head to toe.
ZIYOND has established a comprehensive R&D system for topical dermatological formulations, supporting differentiated product development and sustainable competitive advantages.
The company’s R&D base is located in Xishan District, Wuxi, with more than 3,000 square meters of R&D and pilot-scale facilities. It includes R&D laboratories and pilot research platforms, equipped with professional facilities for formulation development, analytical method development, and stability studies.
The laboratory has obtained CNAS accreditation and completed BSL-2 laboratory registration.
Skin is the largest organ of the human body, and skin diseases are among the most common disease categories worldwide.
ZIYOND remains focused on dermatology and integrates R&D, manufacturing, and sales. The company has built a product ecosystem characterized by broad product variety, complete dosage forms, proven efficacy, and wide category coverage.
This ecosystem is designed to meet multi-level consumer needs, from clinical treatment to daily functional skin care.
● Full Coverage from Head to Toe: The company’s products address skin health needs across the scalp and hair, face, trunk, limbs, and nails.
● Coverage of Common Skin Problems: The company’s products cover common skin problems, including fungal infections, acne and rosacea, eczema, dermatitis, psoriasis, and pigmentary skin diseases.
● R&D Product Layout: As of December 31, 2025, the company focused on six major dermatological disease areas, with more than 110 marketed products and over 30 products under development.
To further strengthen its leadership in China’s dermatology market, ZIYOND plans to launch 15 to 20 new products over the next three to five years.
● Product Efficacy and User Feedback: ZIYOND’s R&D innovation is driven by patient clinical needs. In addition to clinical research, the company has used feedback data from more than 1.7 million real-world users to continuously improve product efficacy, safety, and adherence.
The company integrates consumer-perceivable innovation throughout the R&D process.
In dermatological treatment, drug efficacy depends not only on the active ingredient, but also on the patient’s willingness to use the product.
Heavy or irritating textures may lead patients to discontinue treatment early. Therefore, ZIYOND focuses on solving specific usage barriers during formulation design, rather than only meeting basic compliance requirements.
Based on its proprietary platforms, the company can select suitable dosage forms for different application sites. It has established production lines for eight topical dosage forms, including creams, ointments, gels, solutions, lotions, sprays, liniments, and film-forming topical preparations.
This enables the company to better match patient needs and improve efficacy, adherence, and convenience.
In addition, the company’s integrated R&D and manufacturing system supports efficient technology transfer and quality control, ensuring smooth transition from R&D to commercial production. It also allows flexible adjustment of production volume and product mix according to market demand.
